Gene description for DOK7
Gene name docking protein 7
Gene symbol DOK7
Other names/aliases C4orf25
CMS10
CMS1B
Species Homo sapiens
 Database cross references - DOK7
ExoCarta ExoCarta_285489
Vesiclepedia VP_285489
Entrez Gene 285489
HGNC 26594
MIM 610285
UniProt Q18PE1  
 DOK7 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DOK7
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IDA
Biological Process
    neuromuscular junction development GO:0007528 IBA
    positive regulation of protein tyrosine kinase activity GO:0061098 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IDA
    plasma membrane GO:0005886 IEA
    synapse GO:0045202 IEA
 Experiment description of studies that identified DOK7 in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DOK7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EFEMP2 30008
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DOK7 is involved
No pathways found





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