Gene description for PRKACA
Gene name protein kinase, cAMP-dependent, catalytic, alpha
Gene symbol PRKACA
Other names/aliases -
Species Bos taurus
 Database cross references - PRKACA
ExoCarta ExoCarta_282322
Vesiclepedia VP_282322
Entrez Gene 282322
UniProt P00517  
 PRKACA identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PRKACA
Molecular Function
    cAMP-dependent protein kinase activity GO:0004691 IEA
    ATP binding GO:0005524 IEA
    protein kinase A regulatory subunit binding GO:0034237 IEA
Biological Process
    protein kinase A signaling GO:0010737 IEA
    peptidyl-serine phosphorylation GO:0018105 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cAMP-dependent protein kinase complex GO:0005952 IEA
 Experiment description of studies that identified PRKACA in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRKACA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FOXO1  
Affinity Capture-Western Bos taurus
2 Gabrb1  
Biochemical Activity Mus musculus
3 PPP1R8  
Biochemical Activity Bos taurus
4 GABRR1  
Biochemical Activity Homo sapiens
5 PDE5A  
Biochemical Activity Bos taurus
6 PARK2  
Biochemical Activity Homo sapiens
7 KCNQ1  
Biochemical Activity Homo sapiens
8 NEDD4L 23327
Biochemical Activity Homo sapiens
9 PFKFB2  
Biochemical Activity Bos taurus
View the network image/svg+xml
 Pathways in which PRKACA is involved
PathwayEvidenceSource
Activation of NMDA receptors and postsynaptic events IEA Reactome
Adaptive Immune System IEA Reactome
Anchoring of the basal body to the plasma membrane IEA Reactome
Aquaporin-mediated transport IEA Reactome
AURKA Activation by TPX2 IEA Reactome
Axon guidance IEA Reactome
C-type lectin receptors (CLRs) IEA Reactome
Ca-dependent events IEA Reactome
Calmodulin induced events IEA Reactome
CaM pathway IEA Reactome
Cardiac conduction IEA Reactome
CD209 (DC-SIGN) signaling IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
Centrosome maturation IEA Reactome
Cilium Assembly IEA Reactome
CREB1 phosphorylation through the activation of Adenylate Cyclase IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
DAG and IP3 signaling IEA Reactome
DARPP-32 events IEA Reactome
Developmental Biology IEA Reactome
Factors involved in megakaryocyte development and platelet production IEA Reactome
G alpha (i) signalling events IEA Reactome
G alpha (s) signalling events IEA Reactome
G-protein mediated events IEA Reactome
G2/M Transition IEA Reactome
GLI3 is processed to GLI3R by the proteasome IEA Reactome
Glucagon signaling in metabolic regulation IEA Reactome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion IEA Reactome
GPCR downstream signalling IEA Reactome
GPER1 signaling IEA Reactome
HDL assembly IEA Reactome
Hedgehog 'off' state IEA Reactome
Hemostasis IEA Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Integration of energy metabolism IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Intracellular signaling by second messengers IEA Reactome
Ion homeostasis IEA Reactome
Loss of Nlp from mitotic centrosomes IEA Reactome
Loss of proteins required for interphase microtubule organization from the centrosome IEA Reactome
M Phase IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK6/MAPK4 signaling IEA Reactome
Metabolism IEA Reactome
Metabolism of proteins IEA Reactome
Mitochondrial protein degradation IEA Reactome
Mitotic G2-G2/M phases IEA Reactome
Mitotic Prometaphase IEA Reactome
Muscle contraction IEA Reactome
Nervous system development IEA Reactome
Neuronal System IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Opioid Signalling IEA Reactome
Organelle biogenesis and maintenance IEA Reactome
PKA activation IEA Reactome
PKA activation in glucagon signalling IEA Reactome
PKA-mediated phosphorylation of CREB IEA Reactome
Plasma lipoprotein assembly IEA Reactome
Plasma lipoprotein assembly, remodeling, and clearance IEA Reactome
PLC beta mediated events IEA Reactome
Post NMDA receptor activation events IEA Reactome
Rap1 signalling IEA Reactome
Recruitment of mitotic centrosome proteins and complexes IEA Reactome
Recruitment of NuMA to mitotic centrosomes IEA Reactome
Regulation of insulin secretion IEA Reactome
Regulation of PLK1 Activity at G2/M Transition IEA Reactome
Response of endothelial cells to shear stress IEA Reactome
RET signaling IEA Reactome
Signal Transduction IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by Hedgehog IEA Reactome
Signaling by Interleukins IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by VEGF IEA Reactome
Transmission across Chemical Synapses IEA Reactome
Transport of small molecules IEA Reactome
Vasopressin regulates renal water homeostasis via Aquaporins IEA Reactome
VEGFA-VEGFR2 Pathway IEA Reactome





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