Gene description for GK2
Gene name glycerol kinase 2
Gene symbol GK2
Other names/aliases GKP2
GKTA
Species Homo sapiens
 Database cross references - GK2
ExoCarta ExoCarta_2712
Vesiclepedia VP_2712
Entrez Gene 2712
HGNC 4291
MIM 600148
UniProt Q14410  
 GK2 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for GK2
Molecular Function
    glycerol kinase activity GO:0004370 IBA
    glycerol kinase activity GO:0004370 NAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
Biological Process
    glycerol metabolic process GO:0006071 IBA
    triglyceride metabolic process GO:0006641 IBA
    spermatogenesis GO:0007283 ISS
    glycerol catabolic process GO:0019563 IEA
    flagellated sperm motility GO:0030317 ISS
    glycerol-3-phosphate biosynthetic process GO:0046167 IBA
    sperm mitochondrial sheath assembly GO:0120317 ISS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrial outer membrane GO:0005741 ISS
    extracellular exosome GO:0070062 HDA
    sperm midpiece GO:0097225 IDA
    sperm mitochondrial sheath GO:0097226 ISS
 Experiment description of studies that identified GK2 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GK  
Affinity Capture-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 GK3P  
Affinity Capture-MS Homo sapiens
4 UGP2 7360
Co-fractionation Homo sapiens
5 TP53 7157
Synthetic Growth Defect Homo sapiens
6 HSPA8 3312
Affinity Capture-MS Homo sapiens
7 SLAMF1 6504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GK2 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Triglyceride biosynthesis TAS Reactome
Triglyceride metabolism TAS Reactome





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