Gene description for FUT2
Gene name fucosyltransferase 2 (secretor status included)
Gene symbol FUT2
Other names/aliases B12QTL1
SE
SEC2
Se2
sej
Species Homo sapiens
 Database cross references - FUT2
ExoCarta ExoCarta_2524
Vesiclepedia VP_2524
Entrez Gene 2524
HGNC 4013
MIM 182100
UniProt Q10981  
 FUT2 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Saliva 19199708    
 Gene ontology annotations for FUT2
Molecular Function
    protein binding GO:0005515 IPI
    galactoside 2-alpha-L-fucosyltransferase activity GO:0008107 IBA
    galactoside 2-alpha-L-fucosyltransferase activity GO:0008107 TAS
    fucosyltransferase activity GO:0008417 TAS
    alpha-(1,2)-fucosyltransferase activity GO:0031127 ISS
Biological Process
    regulation of endothelial cell proliferation GO:0001936 ISS
    carbohydrate metabolic process GO:0005975 TAS
    protein glycosylation GO:0006486 IBA
    protein glycosylation GO:0006486 IEA
    protein glycosylation GO:0006486 TAS
    glycolipid metabolic process GO:0006664 ISS
    glycosphingolipid biosynthetic process GO:0006688 TAS
    oligosaccharide biosynthetic process GO:0009312 TAS
    regulation of cell adhesion GO:0030155 ISS
    fucosylation GO:0036065 IBA
    fucosylation GO:0036065 ISS
    L-fucose catabolic process GO:0042355 NAS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 TAS
    Golgi cisterna membrane GO:0032580 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified FUT2 in sEVs
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for FUT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZDHHC17 23390
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here