Gene description for Grin1
Gene name	glutamate receptor, ionotropic, N-methyl D-aspartate 1
Gene symbol	Grin1
Other names/aliases	GluN1 NMDAR1 NR1
Species	Rattus norvegicus
Database cross references - Grin1
ExoCarta	ExoCarta_24408
Vesiclepedia	VP_24408
Entrez Gene	24408
UniProt	P35439
Grin1 identified in sEVs derived from the following tissue/cell type
Cortical neurones	16446100

Gene ontology annotations for Grin1

Molecular Function     amyloid-beta binding GO:0001540 IDA     glutamate-gated receptor activity GO:0004970 IDA     glutamate-gated receptor activity GO:0004970 TAS     NMDA glutamate receptor activity GO:0004972 IBA     NMDA glutamate receptor activity GO:0004972 IDA     NMDA glutamate receptor activity GO:0004972 IGI     NMDA glutamate receptor activity GO:0004972 IMP     NMDA glutamate receptor activity GO:0004972 ISO     NMDA glutamate receptor activity GO:0004972 ISO     NMDA glutamate receptor activity GO:0004972 TAS     signaling receptor binding GO:0005102 IPI     signaling receptor binding GO:0005102 ISO     monoatomic cation channel activity GO:0005261 ISO     calcium channel activity GO:0005262 ISO     calcium channel activity GO:0005262 ISO     calcium ion binding GO:0005509 ISO     protein binding GO:0005515 IPI     calmodulin binding GO:0005516 ISO     ligand-gated monoatomic ion channel activity GO:0015276 IBA     ligand-gated monoatomic ion channel activity GO:0015276 IEA     ligand-gated sodium channel activity GO:0015280 ISO     ligand-gated sodium channel activity GO:0015280 ISS     glycine binding GO:0016594 IDA     glycine binding GO:0016594 ISO     glutamate binding GO:0016595 IDA     glutamate binding GO:0016595 ISO     enzyme binding GO:0019899 IPI     phosphatase binding GO:0019902 IDA     transmitter-gated monoatomic ion channel activity GO:0022824 IDA     voltage-gated monoatomic cation channel activity GO:0022843 IMP     glutamate-gated calcium ion channel activity GO:0022849 ISO     glutamate-gated calcium ion channel activity GO:0022849 ISS     glutamate receptor binding GO:0035254 IPI     ionotropic glutamate receptor binding GO:0035255 IPI     signaling receptor activity GO:0038023 IBA     signaling receptor activity GO:0038023 IEA     protein-containing complex binding GO:0044877 IDA     protein-containing complex binding GO:0044877 IPI     ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099507 EXP     ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099507 IDA     ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099507 IMP     transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 IDA     transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 IMP Biological Process     conditioned taste aversion GO:0001661 ISO     response to hypoxia GO:0001666 IEP     startle response GO:0001964 ISO     suckling behavior GO:0001967 ISO     response to amphetamine GO:0001975 ISO     transcription by RNA polymerase II GO:0006366 ISO     monoatomic cation transport GO:0006812 ISO     monoatomic cation transport GO:0006812 ISO     calcium ion transport GO:0006816 ISO     intracellular calcium ion homeostasis GO:0006874 ISO     chemical synaptic transmission GO:0007268 IBA     learning or memory GO:0007611 ISO     learning or memory GO:0007611 TAS     learning GO:0007612 ISO     memory GO:0007613 ISO     long-term memory GO:0007616 ISO     associative learning GO:0008306 ISO     adult locomotory behavior GO:0008344 ISO     olfactory learning GO:0008355 ISO     visual learning GO:0008542 ISO     positive regulation of calcium ion transport into cytosol GO:0010524 IGI     regulation of cell communication GO:0010646 ISO     response to organic cyclic compound GO:0014070 IEP     response to amine GO:0014075 IEP     propylene metabolic process GO:0018964 ISO     sensory perception of pain GO:0019233 ISO     calcium-mediated signaling GO:0019722 IEA     pons maturation GO:0021586 ISO     cerebral cortex development GO:0021987 ISO     monoatomic ion transmembrane transport GO:0034220 IEA     social behavior GO:0035176 ISO     ionotropic glutamate receptor signaling pathway GO:0035235 IBA     ionotropic glutamate receptor signaling pathway GO:0035235 IDA     ionotropic glutamate receptor signaling pathway GO:0035235 IEA     ionotropic glutamate receptor signaling pathway GO:0035235 ISO     ionotropic glutamate receptor signaling pathway GO:0035235 ISO     ionotropic glutamate receptor signaling pathway GO:0035235 ISS     synaptic transmission, glutamatergic GO:0035249 ISO     sodium ion transmembrane transport GO:0035725 ISO     sodium ion transmembrane transport GO:0035725 ISS     regulation of membrane potential GO:0042391 IBA     regulation of membrane potential GO:0042391 ISO     regulation of membrane potential GO:0042391 ISO     positive regulation of apoptotic process GO:0043065 ISO     response to morphine GO:0043278 ISO     regulation of neuron apoptotic process GO:0043523 ISO     negative regulation of neuron apoptotic process GO:0043524 ISO     regulation of respiratory gaseous exchange GO:0043576 ISO     response to ethanol GO:0045471 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     regulation of synaptic plasticity GO:0048167 ISO     regulation of synaptic plasticity GO:0048167 ISS     regulation of neuronal synaptic plasticity GO:0048168 ISO     regulation of neuronal synaptic plasticity GO:0048168 NAS     regulation of long-term neuronal synaptic plasticity GO:0048169 ISO     rhythmic process GO:0048511 IDA     regulation of dendrite morphogenesis GO:0048814 ISO     regulation of axonogenesis GO:0050770 ISO     neuromuscular process GO:0050905 ISO     protein heterotetramerization GO:0051290 IDA     response to calcium ion GO:0051592 IEP     regulation of synapse assembly GO:0051963 ISO     positive regulation of synaptic transmission, glutamatergic GO:0051968 IDA     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISS     calcium ion homeostasis GO:0055074 ISO     excitatory postsynaptic potential GO:0060079 ISO     prepulse inhibition GO:0060134 ISO     male mating behavior GO:0060179 ISO     response to fungicide GO:0060992 IEP     protein-containing complex assembly GO:0065003 IDA     neuron cellular homeostasis GO:0070050 ISO     calcium ion transmembrane transport GO:0070588 IDA     calcium ion transmembrane transport GO:0070588 ISO     calcium ion transmembrane transport GO:0070588 ISS     cellular response to manganese ion GO:0071287 IEP     calcium ion transmembrane import into cytosol GO:0097553 ISO     monoatomic cation transmembrane transport GO:0098655 IDA     monoatomic cation transmembrane transport GO:0098655 ISO     monoatomic cation transmembrane transport GO:0098655 ISS     regulation of presynaptic membrane potential GO:0099505 IEA     positive regulation of Schwann cell migration GO:1900149 IMP     positive regulation of dendritic spine maintenance GO:1902952 IGI     positive regulation of reactive oxygen species biosynthetic process GO:1903428 IGI     protein localization to postsynaptic membrane GO:1903539 ISO     regulation of monoatomic cation transmembrane transport GO:1904062 IDA     regulation of monoatomic cation transmembrane transport GO:1904062 ISS     cellular response to amyloid-beta GO:1904646 ISO     response to glycine GO:1905429 ISO     cellular response to glycine GO:1905430 IEP     positive regulation of excitatory postsynaptic potential GO:2000463 IDA     positive regulation of excitatory postsynaptic potential GO:2000463 ISS Subcellular Localization     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum membrane GO:0005789 TAS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 TAS     synaptic vesicle GO:0008021 ISO     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     postsynaptic density GO:0014069 ISO     membrane GO:0016020 ISO     basolateral plasma membrane GO:0016323 ISO     NMDA selective glutamate receptor complex GO:0017146 IBA     NMDA selective glutamate receptor complex GO:0017146 IDA     NMDA selective glutamate receptor complex GO:0017146 IEA     NMDA selective glutamate receptor complex GO:0017146 ISO     NMDA selective glutamate receptor complex GO:0017146 ISS     NMDA selective glutamate receptor complex GO:0017146 TAS     dendrite GO:0030425 ISO     synaptic vesicle membrane GO:0030672 ISO     dendrite membrane GO:0032590 IDA     monoatomic ion channel complex GO:0034702 ISO     presynaptic membrane GO:0042734 IDA     presynaptic membrane GO:0042734 IDA     neuron projection GO:0043005 IBA     neuronal cell body GO:0043025 IDA     neuronal cell body GO:0043025 ISO     synaptic cleft GO:0043083 IDA     terminal bouton GO:0043195 IDA     dendritic spine GO:0043197 IDA     dendritic spine GO:0043197 ISO     dendritic branch GO:0044307 IDA     synapse GO:0045202 IBA     synapse GO:0045202 IDA     synapse GO:0045202 ISO     postsynaptic membrane GO:0045211 IDA     postsynaptic membrane GO:0045211 IEA     postsynaptic membrane GO:0045211 ISO     postsynaptic membrane GO:0045211 NAS     presynaptic active zone membrane GO:0048787 IDA     excitatory synapse GO:0060076 IDA     synaptic membrane GO:0097060 IDA     synaptic membrane GO:0097060 IPI     synaptic membrane GO:0097060 ISO     hippocampal mossy fiber to CA3 synapse GO:0098686 IDA     parallel fiber to Purkinje cell synapse GO:0098688 IDA     postsynaptic density membrane GO:0098839 IDA     postsynaptic density membrane GO:0098839 IDA     postsynaptic density membrane GO:0098839 ISO     neurotransmitter receptor complex GO:0098878 ISO     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IMP     glutamatergic synapse GO:0098978 ISO