Gene description for DDN
Gene name dendrin
Gene symbol DDN
Other names/aliases -
Species Homo sapiens
 Database cross references - DDN
ExoCarta ExoCarta_23109
Vesiclepedia VP_23109
Entrez Gene 23109
HGNC 24458
MIM 610588
UniProt O94850  
 DDN identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DDN
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    dendritic spine membrane GO:0032591 IEA
    cell projection GO:0042995 IDA
    perikaryon GO:0043204 IEA
    postsynaptic membrane GO:0045211 IEA
    presynapse GO:0098793 IEA
 Experiment description of studies that identified DDN in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DDN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 MAGI1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
3 ACTN1 87
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
View the network image/svg+xml
 Pathways in which DDN is involved
No pathways found





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