Gene description for Ndrg1
Gene name N-myc downstream regulated gene 1
Gene symbol Ndrg1
Other names/aliases CAP43
CMT4D
DRG1
HMSNL
NMSL
Ndr1
Ndrl
PROXY1
RTP
TDD5
Species Mus musculus
 Database cross references - Ndrg1
ExoCarta ExoCarta_17988
Vesiclepedia VP_17988
Entrez Gene 17988
UniProt Q62433  
 Ndrg1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ndrg1
Molecular Function
    microtubule binding GO:0008017 IEA
    microtubule binding GO:0008017 ISO
    small GTPase binding GO:0031267 IEA
    small GTPase binding GO:0031267 ISO
    gamma-tubulin binding GO:0043015 IEA
    gamma-tubulin binding GO:0043015 ISO
    cadherin binding GO:0045296 IEA
    cadherin binding GO:0045296 ISO
Biological Process
    signal transduction GO:0007165 IBA
    negative regulation of cell population proliferation GO:0008285 IMP
    DNA damage response, signal transduction by p53 class mediator GO:0030330 IEA
    peripheral nervous system myelin maintenance GO:0032287 IMP
    mast cell activation GO:0045576 IDA
    cellular response to hypoxia GO:0071456 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    microtubule GO:0005874 IEA
    microtubule GO:0005874 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    adherens junction GO:0005912 IEA
    adherens junction GO:0005912 ISO
    microtubule cytoskeleton GO:0015630 ISO
    myelin sheath GO:0043209 HDA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    recycling endosome membrane GO:0055038 IEA
    recycling endosome membrane GO:0055038 ISO
 Experiment description of studies that identified Ndrg1 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ndrg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zer1  
Co-fractionation Mus musculus
2 Lnx1  
Affinity Capture-MS Mus musculus
3 Sstr3  
Proximity Label-MS Mus musculus
4 Upf1 19704
Co-fractionation Mus musculus
5 Ruvbl2 20174
Co-fractionation Mus musculus
6 Map2k6  
Co-fractionation Mus musculus
7 Tmsb4x  
Co-fractionation Mus musculus
8 Tprgl  
Co-fractionation Mus musculus
9 Nt5c3b  
Co-fractionation Mus musculus
10 Ptgds  
Co-fractionation Mus musculus
11 Kcnma1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Ndrg1 is involved
No pathways found





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