Gene description for Krt16
Gene name keratin 16
Gene symbol Krt16
Other names/aliases AI324768
K16
Krt1-16
Species Mus musculus
 Database cross references - Krt16
ExoCarta ExoCarta_16666
Vesiclepedia VP_16666
Entrez Gene 16666
UniProt Q9Z2K1  
 Krt16 identified in sEVs derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt16
Molecular Function
    structural constituent of cytoskeleton GO:0005200 IDA
    protein binding GO:0005515 IPI
Biological Process
    morphogenesis of an epithelium GO:0002009 IMP
    inflammatory response GO:0006954 IMP
    keratinocyte differentiation GO:0030216 IDA
    negative regulation of cell migration GO:0030336 IEA
    negative regulation of cell migration GO:0030336 ISO
    epithelial cell differentiation GO:0030855 IBA
    keratinization GO:0031424 IDA
    hair cycle GO:0042633 IEA
    hair cycle GO:0042633 ISO
    innate immune response GO:0045087 IMP
    intermediate filament cytoskeleton organization GO:0045104 IDA
    intermediate filament organization GO:0045109 IBA
    keratinocyte migration GO:0051546 IDA
    establishment of skin barrier GO:0061436 IMP
Subcellular Localization
    cornified envelope GO:0001533 IDA
    cytoskeleton GO:0005856 IBA
    cytoskeleton GO:0005856 ISO
    intermediate filament GO:0005882 IDA
    keratin filament GO:0045095 IBA
 Experiment description of studies that identified Krt16 in sEVs
1
Experiment ID 33
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C1qc  
Co-fractionation Mus musculus
2 Eps15 13858
Co-fractionation Mus musculus
3 Nphp4  
Affinity Capture-MS Mus musculus
4 Inppl1  
Co-fractionation Mus musculus
5 Atxn1  
Proximity Label-MS Mus musculus
6 Pik3r2  
Co-fractionation Mus musculus
7 Kctd13  
Affinity Capture-MS Mus musculus
8 Thrb  
Affinity Capture-MS Mus musculus
9 Ahi1  
Affinity Capture-MS Mus musculus
10 Ubash3b  
Co-fractionation Mus musculus
11 Mks1  
Affinity Capture-MS Mus musculus
12 Iqcb1  
Affinity Capture-MS Mus musculus
13 Nanog  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Krt16 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Formation of the cornified envelope IEA Reactome
Keratinization IEA Reactome





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