Gene description for Eif6
Gene name eukaryotic translation initiation factor 6
Gene symbol Eif6
Other names/aliases 1110004P11
AA408895
CAB
Itgb4bp
eIF-6
imc-415
p27(BBP)
p27BBP
Species Mus musculus
 Database cross references - Eif6
ExoCarta ExoCarta_16418
Vesiclepedia VP_16418
Entrez Gene 16418
UniProt O55135  
 Eif6 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Eif6
Molecular Function
    translation initiation factor activity GO:0003743 IEA
    ribosome binding GO:0043022 ISO
    ribosome binding GO:0043022 ISS
    ribosomal large subunit binding GO:0043023 IBA
    ribosomal large subunit binding GO:0043023 IEA
Biological Process
    ribosomal subunit export from nucleus GO:0000054 IBA
    ribosomal subunit export from nucleus GO:0000054 IEA
    maturation of 5.8S rRNA GO:0000460 IBA
    maturation of LSU-rRNA GO:0000470 IBA
    regulation of glycolytic process GO:0006110 IMP
    translational initiation GO:0006413 IEA
    response to insulin GO:0032868 IMP
    miRNA-mediated post-transcriptional gene silencing GO:0035195 ISO
    miRNA-mediated post-transcriptional gene silencing GO:0035195 ISS
    miRNA-mediated gene silencing by inhibition of translation GO:0035278 ISO
    miRNA-mediated gene silencing by inhibition of translation GO:0035278 ISS
    cytosolic ribosome assembly GO:0042256 ISO
    cytosolic ribosome assembly GO:0042256 ISS
    ribosomal large subunit biogenesis GO:0042273 IEA
    regulation of fatty acid biosynthetic process GO:0042304 IMP
    regulation of megakaryocyte differentiation GO:0045652 IMP
    positive regulation of translation GO:0045727 IMP
    assembly of large subunit precursor of preribosome GO:1902626 IBA
    regulation of reactive oxygen species metabolic process GO:2000377 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    lamin filament GO:0005638 IDA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
    intermediate filament GO:0005882 IDA
    synapse GO:0045202 EXP
    synapse GO:0045202 IDA
 Experiment description of studies that identified Eif6 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Eif6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Psme1 19186
Co-fractionation Mus musculus
2 Elf5  
Affinity Capture-MS Mus musculus
3 Atxn1  
Affinity Capture-MS Mus musculus
4 Rpl19 19921
Co-fractionation Mus musculus
5 Eed  
Affinity Capture-MS Mus musculus
6 Rpl12 269261
Co-fractionation Mus musculus
7 Rpl6 19988
Co-fractionation Mus musculus
8 Atg16l1  
Affinity Capture-MS Mus musculus
9 Rpl7 19989
Co-fractionation Mus musculus
10 Rplp2 67186
Co-fractionation Mus musculus
11 Nanog  
Affinity Capture-MS Mus musculus
12 Fancd2  
Affinity Capture-MS Mus musculus
13 Rpl30 19946
Co-fractionation Mus musculus
14 Rpl13 270106
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Eif6 is involved
No pathways found





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