Gene description for Igf2bp3
Gene name insulin-like growth factor 2 mRNA binding protein 3
Gene symbol Igf2bp3
Other names/aliases 2610101N11Rik
AA522010
AL022933
AU045931
IMP-3
IMP3
Koc13
Neilsen
mimp3
Species Mus musculus
 Database cross references - Igf2bp3
ExoCarta ExoCarta_140488
Vesiclepedia VP_140488
Entrez Gene 140488
UniProt Q9CPN8  
 Igf2bp3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Igf2bp3
Molecular Function
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 ISO
    mRNA 3'-UTR binding GO:0003730 ISS
    protein binding GO:0005515 IPI
    mRNA 5'-UTR binding GO:0048027 IEA
    mRNA 5'-UTR binding GO:0048027 ISO
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISO
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISS
Biological Process
    regulation of translation GO:0006417 IEA
    nervous system development GO:0007399 IBA
    mRNA transport GO:0051028 IEA
    CRD-mediated mRNA stabilization GO:0070934 IBA
    CRD-mediated mRNA stabilization GO:0070934 ISO
    CRD-mediated mRNA stabilization GO:0070934 ISS
Subcellular Localization
    P-body GO:0000932 ISO
    P-body GO:0000932 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytoplasmic stress granule GO:0010494 ISO
    cytoplasmic stress granule GO:0010494 ISS
 Experiment description of studies that identified Igf2bp3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Igf2bp3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hnrnpk 15387
Two-hybrid Mus musculus
2 PCBP3 54039
Two-hybrid Homo sapiens
3 Foxp3  
Affinity Capture-MS Mus musculus
4 MKRN1 23608
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Igf2bp3 is involved
No pathways found





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