Gene description for Cd38
Gene name CD38 antigen
Gene symbol Cd38
Other names/aliases ADPRC 1
Cd38-rs1
Species Mus musculus
 Database cross references - Cd38
ExoCarta ExoCarta_12494
Vesiclepedia VP_12494
Entrez Gene 12494
UniProt P56528  
 Cd38 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cd38
Molecular Function
    NAD+ nucleosidase activity GO:0003953 IEA
    transferase activity GO:0016740 IEA
    hydrolase activity, acting on glycosyl bonds GO:0016798 IMP
    phosphorus-oxygen lyase activity GO:0016849 IBA
    phosphorus-oxygen lyase activity GO:0016849 IMP
    identical protein binding GO:0042802 IPI
    NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 IEA
    NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 ISO
Biological Process
    response to hypoxia GO:0001666 IEA
    response to hypoxia GO:0001666 ISO
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    female pregnancy GO:0007565 IEA
    positive regulation of cell population proliferation GO:0008284 ISO
    response to xenobiotic stimulus GO:0009410 IEA
    response to xenobiotic stimulus GO:0009410 ISO
    response to hormone GO:0009725 ISO
    negative regulation of neuron projection development GO:0010977 IEA
    negative regulation of neuron projection development GO:0010977 ISO
    artery smooth muscle contraction GO:0014824 IEA
    artery smooth muscle contraction GO:0014824 ISO
    positive regulation of cell growth GO:0030307 IEA
    positive regulation of cell growth GO:0030307 ISO
    positive regulation of B cell proliferation GO:0030890 IBA
    positive regulation of B cell proliferation GO:0030890 IDA
    positive regulation of B cell proliferation GO:0030890 ISO
    positive regulation of insulin secretion GO:0032024 IEA
    positive regulation of insulin secretion GO:0032024 ISO
    response to estradiol GO:0032355 IEA
    response to retinoic acid GO:0032526 IEA
    response to progesterone GO:0032570 IEA
    response to hydroperoxide GO:0033194 IEA
    response to hydroperoxide GO:0033194 ISO
    B cell proliferation GO:0042100 IDA
    negative regulation of apoptotic process GO:0043066 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of bone resorption GO:0045779 IEA
    negative regulation of bone resorption GO:0045779 ISO
    negative regulation of DNA-templated transcription GO:0045892 IEA
    negative regulation of DNA-templated transcription GO:0045892 ISO
    positive regulation of DNA-templated transcription GO:0045893 IEA
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of vasoconstriction GO:0045907 IEA
    positive regulation of vasoconstriction GO:0045907 ISO
    B cell receptor signaling pathway GO:0050853 IEA
    B cell receptor signaling pathway GO:0050853 ISO
    long-term synaptic depression GO:0060292 IEA
    long-term synaptic depression GO:0060292 ISO
    response to interleukin-1 GO:0070555 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    cell surface GO:0009986 IDA
    membrane GO:0016020 IDA
    basolateral plasma membrane GO:0016323 IEA
    basolateral plasma membrane GO:0016323 ISO
    nuclear membrane GO:0031965 IEA
    nuclear membrane GO:0031965 ISO
 Experiment description of studies that identified Cd38 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cd38
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Lck 16818
Affinity Capture-Western Mus musculus
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