Gene description for Mat1a
Gene name methionine adenosyltransferase I, alpha
Gene symbol Mat1a
Other names/aliases AI046368
AdoMet
Ams
MAT
MATA1
SAMS
SAMS1
Species Mus musculus
 Database cross references - Mat1a
ExoCarta ExoCarta_11720
Vesiclepedia VP_11720
Entrez Gene 11720
UniProt Q91X83  
 Mat1a identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mat1a
Molecular Function
    magnesium ion binding GO:0000287 ISO
    methionine adenosyltransferase activity GO:0004478 IBA
    methionine adenosyltransferase activity GO:0004478 ISO
    methionine adenosyltransferase activity GO:0004478 ISS
    methionine adenosyltransferase activity GO:0004478 TAS
    ATP binding GO:0005524 IEA
    ATP binding GO:0005524 ISO
    amino acid binding GO:0016597 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    ADP binding GO:0043531 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    S-adenosylmethionine biosynthetic process GO:0006556 IBA
    S-adenosylmethionine biosynthetic process GO:0006556 IEA
    S-adenosylmethionine biosynthetic process GO:0006556 ISO
    S-adenosylmethionine biosynthetic process GO:0006556 ISS
    one-carbon metabolic process GO:0006730 IEA
    methionine catabolic process GO:0009087 ISO
    methionine catabolic process GO:0009087 ISS
    protein homotetramerization GO:0051289 IEA
    protein homotetramerization GO:0051289 ISO
    protein-containing complex assembly GO:0065003 ISO
Subcellular Localization
    cytosol GO:0005829 IBA
    nuclear matrix GO:0016363 ISO
    methionine adenosyltransferase complex GO:0048269 IEA
    methionine adenosyltransferase complex GO:0048269 ISO
 Experiment description of studies that identified Mat1a in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mat1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 App 11820
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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