Gene description for ADCY3
Gene name adenylate cyclase 3
Gene symbol ADCY3
Other names/aliases AC3
Species Homo sapiens
 Database cross references - ADCY3
ExoCarta ExoCarta_109
Vesiclepedia VP_109
Entrez Gene 109
HGNC 234
MIM 600291
UniProt O60266  
 ADCY3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ADCY3
Molecular Function
    adenylate cyclase activity GO:0004016 IBA
    adenylate cyclase activity GO:0004016 ISS
    calmodulin binding GO:0005516 IEA
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    cAMP biosynthetic process GO:0006171 IBA
    cAMP biosynthetic process GO:0006171 ISS
    signal transduction GO:0007165 TAS
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 ISS
    single fertilization GO:0007338 ISS
    acrosome reaction GO:0007340 ISS
    sensory perception of smell GO:0007608 ISS
    olfactory learning GO:0008355 ISS
    flagellated sperm motility GO:0030317 ISS
    intracellular signal transduction GO:0035556 IEA
    cellular response to forskolin GO:1904322 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 ISS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    cilium GO:0005929 ISS
    membrane GO:0016020 HDA
    membrane GO:0016020 ISS
    ciliary membrane GO:0060170 ISS
 Experiment description of studies that identified ADCY3 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADCY3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STUB1 10273
Affinity Capture-MS Homo sapiens
2 RELT  
Affinity Capture-MS Homo sapiens
3 CYP26B1  
Affinity Capture-MS Homo sapiens
4 SLC17A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 RAB35 11021
Proximity Label-MS Homo sapiens
6 OR10H1  
Affinity Capture-MS Homo sapiens
7 IZUMO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SLC30A2  
Affinity Capture-MS Homo sapiens
9 C1orf43 25912
Affinity Capture-MS Homo sapiens
10 TTYH1  
Affinity Capture-MS Homo sapiens
11 RXFP1  
Affinity Capture-MS Homo sapiens
12 CIB2  
Affinity Capture-MS Homo sapiens
13 PCDHGA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 MTNR1B  
Two-hybrid Homo sapiens
16 ZDHHC12  
Affinity Capture-MS Homo sapiens
17 PTCH2  
Affinity Capture-MS Homo sapiens
18 TCIRG1 10312
Affinity Capture-MS Homo sapiens
19 ADRB2  
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
20 LGALS3 3958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CCDC107  
Affinity Capture-MS Homo sapiens
22 TSPAN17 26262
Affinity Capture-MS Homo sapiens
23 TMEM9B 56674
Affinity Capture-MS Homo sapiens
24 KLRC2  
Affinity Capture-MS Homo sapiens
25 DDX58 23586
Affinity Capture-RNA Homo sapiens
26 LYN 4067
Proximity Label-MS Homo sapiens
27 MCAM 4162
Proximity Label-MS Homo sapiens
28 TLR9  
Affinity Capture-MS Homo sapiens
29 APEX1 328
Affinity Capture-RNA Homo sapiens
30 KCNE3  
Affinity Capture-MS Homo sapiens
31 MS4A15  
Affinity Capture-MS Homo sapiens
32 CHRNB4  
Affinity Capture-MS Homo sapiens
33 ANKMY2 57037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 KCNMB3  
Affinity Capture-MS Homo sapiens
35 FAM57A  
Affinity Capture-MS Homo sapiens
36 SLC4A8 9498
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 LHFPL1  
Affinity Capture-MS Homo sapiens
38 MARCH4  
Affinity Capture-MS Homo sapiens
39 CNGA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 ASIC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 KRAS 3845
Proximity Label-MS Homo sapiens
42 ABCA2 20
Affinity Capture-MS Homo sapiens
43 RHOB 388
Proximity Label-MS Homo sapiens
44 IL17RC 84818
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PIGH  
Affinity Capture-MS Homo sapiens
46 CAV1 857
Proximity Label-MS Homo sapiens
47 AQP9  
Affinity Capture-MS Homo sapiens
48 DCST1  
Affinity Capture-MS Homo sapiens
49 C3orf52  
Affinity Capture-MS Homo sapiens
50 CYP19A1  
Affinity Capture-MS Homo sapiens
51 KCNA5  
Affinity Capture-MS Homo sapiens
52 PCDHB3  
Affinity Capture-MS Homo sapiens
53 POPDC2  
Affinity Capture-MS Homo sapiens
54 CLRN2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ADCY3 is involved
PathwayEvidenceSource
Activation of GABAB receptors IEA Reactome
Activation of GABAB receptors TAS Reactome
Adenylate cyclase activating pathway TAS Reactome
Adenylate cyclase inhibitory pathway IEA Reactome
Adenylate cyclase inhibitory pathway TAS Reactome
ADORA2B mediated anti-inflammatory cytokines production IEA Reactome
ADORA2B mediated anti-inflammatory cytokines production TAS Reactome
Anti-inflammatory response favouring Leishmania parasite infection IEA Reactome
Anti-inflammatory response favouring Leishmania parasite infection TAS Reactome
Aquaporin-mediated transport TAS Reactome
Ca-dependent events TAS Reactome
Calmodulin induced events TAS Reactome
CaM pathway TAS Reactome
Cellular responses to mechanical stimuli TAS Reactome
Cellular responses to stimuli TAS Reactome
DAG and IP3 signaling TAS Reactome
Disease IEA Reactome
Disease TAS Reactome
FCGR3A-mediated IL10 synthesis TAS Reactome
G alpha (i) signalling events IEA Reactome
G alpha (i) signalling events TAS Reactome
G alpha (s) signalling events IEA Reactome
G alpha (s) signalling events TAS Reactome
G alpha (z) signalling events IEA Reactome
G alpha (z) signalling events TAS Reactome
G-protein mediated events IEA Reactome
G-protein mediated events TAS Reactome
GABA B receptor activation IEA Reactome
GABA B receptor activation TAS Reactome
GABA receptor activation IEA Reactome
GABA receptor activation TAS Reactome
Glucagon signaling in metabolic regulation TAS Reactome
GPCR downstream signalling IEA Reactome
GPCR downstream signalling TAS Reactome
GPER1 signaling IEA Reactome
GPER1 signaling TAS Reactome
Hedgehog 'off' state TAS Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells TAS Reactome
Infectious disease IEA Reactome
Infectious disease TAS Reactome
Integration of energy metabolism TAS Reactome
Intracellular signaling by second messengers TAS Reactome
Leishmania infection IEA Reactome
Leishmania infection TAS Reactome
Leishmania parasite growth and survival IEA Reactome
Leishmania parasite growth and survival TAS Reactome
Metabolism TAS Reactome
Neuronal System IEA Reactome
Neuronal System TAS Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission TAS Reactome
Olfactory Signaling Pathway IEA Reactome
Opioid Signalling IEA Reactome
Opioid Signalling TAS Reactome
Parasitic Infection Pathways IEA Reactome
Parasitic Infection Pathways TAS Reactome
PKA activation TAS Reactome
PKA activation in glucagon signalling TAS Reactome
PKA-mediated phosphorylation of CREB TAS Reactome
PLC beta mediated events TAS Reactome
Response of endothelial cells to shear stress TAS Reactome
Sensory Perception IEA Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by GPCR IEA Reactome
Signaling by GPCR TAS Reactome
Signaling by Hedgehog TAS Reactome
Transmission across Chemical Synapses IEA Reactome
Transmission across Chemical Synapses TAS Reactome
Transport of small molecules TAS Reactome
Vasopressin regulates renal water homeostasis via Aquaporins TAS Reactome





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