Gene description for RAPGEF3
Gene name	Rap guanine nucleotide exchange factor (GEF) 3
Gene symbol	RAPGEF3
Other names/aliases	CAMP-GEFI EPAC EPAC1 HSU79275 bcm910
Species	Homo sapiens
Database cross references - RAPGEF3
ExoCarta	ExoCarta_10411
Vesiclepedia	VP_10411
Entrez Gene	10411
HGNC	16629
MIM	606057
UniProt	O95398
RAPGEF3 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells	25944692
Urine	19056867

Gene ontology annotations for RAPGEF3

Molecular Function     guanyl-nucleotide exchange factor activity GO:0005085 EXP     guanyl-nucleotide exchange factor activity GO:0005085 IBA     guanyl-nucleotide exchange factor activity GO:0005085 IMP     protein binding GO:0005515 IPI     protein domain specific binding GO:0019904 IPI     cAMP binding GO:0030552 TAS Biological Process     angiogenesis GO:0001525 IEA     adaptive immune response GO:0002250 TAS     signal transduction GO:0007165 TAS     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 NAS     Ras protein signal transduction GO:0007265 IBA     associative learning GO:0008306 IEA     Rap protein signal transduction GO:0032486 IMP     regulation of actin cytoskeleton organization GO:0032956 IMP     negative regulation of syncytium formation by plasma membrane fusion GO:0034242 IMP     intracellular signal transduction GO:0035556 IMP     positive regulation of GTPase activity GO:0043547 IMP     regulation of angiogenesis GO:0045765 IMP     positive regulation of angiogenesis GO:0045766 IMP     positive regulation of protein export from nucleus GO:0046827 IDA     regulation of insulin secretion GO:0050796 TAS     positive regulation of stress fiber assembly GO:0051496 IMP     regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 IMP     positive regulation of syncytium formation by plasma membrane fusion GO:0060143 IMP     establishment of endothelial barrier GO:0061028 IMP     cellular response to cAMP GO:0071320 IDA Subcellular Localization     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     microvillus GO:0005902 IDA     endomembrane system GO:0012505 IEA     membrane GO:0016020 TAS     lamellipodium GO:0030027 IDA     filopodium GO:0030175 IDA     cortical actin cytoskeleton GO:0030864 IDA     extracellular exosome GO:0070062 HDA